Erectile Dysfunction Drug Shows Promise For Relief Of Lower Urinary Tract Symptoms
Erectile Dysfunction Drug Shows Promise For Relief Of Lower Urinary Tract Symptoms Associated With Benign Prostate Disease.
Men with signs of benign prostatic hyperplasia (BPH) can be helped with a daily dose of erectile dysfunction drug canadian Cialis to relieve associated lower urinary tract symptoms (LUTS), according to a new study published in the October 2008 issue of The Journal of Urology. Researchers from the University of Texas Southwestern Medical Center at Dallas and Northwestern University report on a randomized, double-blind, placebo-controlled study of over 1000 men in ten countries.
Claus G. Roehrborn, MD, Professor of Urology, University of Texas Southwestern Medical Center, states, “Since reports of erectile dysfunction (ED) incidence, pathophysiology and treatment have shown a possible link between BPH LUTS and ED. PDE5 inhibitors like cialis super active have received increased attention for treating BPH LUTS, although they are currently only approved for ED. The half-life of cialis super active+ is 17.5 hours, making it suitable as once daily therapy. Although the precise mechanism of action by which PDE5 inhibitors may alleviate LUTS is not completely understood, several putative mechanisms are currently under investigation.”
Men with signs of BPH may experience LUTS, such as urinary frequency, urgency, intermittence, nocturia, straining, incomplete emptying or a weak urinary stream. LUTS increase with age with an overall prevalence of greater than 50% in men 50 years or older. Drugs currently used to treat these symptoms can produce unwanted side effects, including dizziness, low blood pressure and sexual dysfunction.
Participants in the cheap tadalafil study were required to have at least a 6-month history of LUTS secondary to BPH. Subjects with a high PSA (more than 10 ng/ml) were excluded, as were subjects with other complicating conditions or conflicting drug treatments. Anyone who had undergone treatment for erectile dysfunction or other BPH treatments underwent a 4-week treatment-free screening period. All participants then received placebo for 4 weeks prior to randomization. The 1056 subjects were then divided randomly into 5 groups that received a placebo, or doses of 2.5, 5.0, 10.0 or 20.0 mg/day of tadalafil.
Using the International Prostate Symptom Score (I-PSS), a validated seven-item questionnaire about LUTS occurring within the last month, the researchers found that all doses of cialis professional were superior to placebo for relieving LUTS, with statistically significant effects at 4, 8 and 12 weeks. The treatments decreased I-PSS scores from 3.9 to 5.2 points in the different dosage groups, a clinically meaningful improvement according to the guidelines of the American Urological Association. Of the doses studied, 5 mg per day improved the I-PSS by 4.9 points and provided the best risk-benefit profile.
Low Testosterone May Cause Health Problems That Lead To Erectile Dysfunction
Men with erectile dysfunction should be examined for testosterone deficiency and the metabolic syndrome, because these conditions commonly occur together, a new study shows.
“Erectile dysfunction is a portal into men’s health,” said the study’s senior author, Aksam Yassin, MD, PhD, of the Clinic for Urology and Andrology of the Segeberger Clinics in Norderstedt, Germany. “It is becoming clear that obesity, diabetes, high blood pressure, cholesterol problems and erectile difficulties are intertwined, and a common denominator is testosterone deficiency.”
Yassin’s research, performed with scientists from The Netherlands, Germany and the United Arab Emirates, aimed to determine in men with erectile dysfunction (ED) the prevalence of hypogonadism, the scientific term for testosterone deficiency.
Over a two-year period the investigators studied 771 patients who sought treatment for ED. Their average age was 56. The patients received a comprehensive screening for low testosterone and indicators of the metabolic syndrome, a cluster of risk factors that increase the chances of developing heart and vascular disease and type 2 diabetes. Having three of the following five risk factors establishes the diagnosis of this syndrome: increased waist circumference (abdominal fat), low HDL (“good”) cholesterol, high triglycerides (fats in the blood), high blood pressure, and high blood sugar.
Among the 771 men, 18.3 percent of the men (141 men) had testosterone deficiency, which had previously been undetected, the authors found. The prevalence of hypogonadism in the general population of men age 45 and older is about 12 percent, Yassin said.
Of all the men in the study, 270 (35 percent) had type 1 or type 2 diabetes; in eight of the men, diabetes was a new diagnosis, according to study data. High blood pressure was found in 239 men (31 percent), and 12 of these men had been unaware of it. Among the 162 men (21 percent) who had dyslipidemia—abnormal cholesterol or triglycerides—nine of them had not previously been diagnosed. And 108 men, or 14 percent, had varying degrees of coronary heart disease. Five of them received this diagnosis for the first time, Yassin said.
Men with ED—especially older men—should therefore receive evaluation not only for ED but also for testosterone deficiency and any underlying signs of the metabolic syndrome, he advised. Cialis Professional: get treatment for erectile dysfunction.
Detailed results were recently presented at The Endocrine Society’s 90th Annual Meeting in San Francisco. Yassin disclosed that he is on the speakers’ bureau for Bayer Schering, which makes a brand of testosterone.
Erectile Dysfunction: Group Psychotherapy Can Help
Taking part in group psychotherapy can help men who have erectile dysfunction to over come their problem, and adding cheap cialis to group therapy was more effective that generic cialis online alone. In addition, group psychotherapy was more effective than taking sildenafil on its own, a Cochrane Systematic Review has found.
Normal sexual function relies on the coordination of psychological, endocrine, vascular and neurological factor. Recent research has increased attention on the role of psychological issues. In particular, depression, low self-esteem, anxiety and other psychosocial stresses can play a large role in male impotence.
A team of Cochrane Researchers drew data from nine randomised trials and two quasi-randomised trials. These involved 398 men with erectile dysfunction who had been given psychotherapy, medication, psychotherapy plus medication or vacuum devices. A further 59 were in non-treatment control groups.
Buy Cialis Online – Great Pill for Male Impotence and Erectile Dysfunction:
“We found that 95% of men in the psychosocial therapy group benefited from the treatment, while there was no change in over the same period of time in the controls,” says Professor Tamara Melnik, a psychiatrists working at the Universidade de São Paulo in Brazil.
“We now need some large randomised trials with longer follow-up periods in order to measure exactly how effective psychosocial therapy can be. This research will need to group the men carefully, and also consider different forms of psychosocial treatment,” says Melnik.
Cialis | Comments (0)“One problem with psychosocial therapy is that we are still uncertain which patients are most likely to benefit from it and if effectiveness depend upon personality factors, psychiatric co-morbid diagnosis, length of therapy time,” says Melnik.
